Resources, Diagrams, and Decision Trees

Side Effect Risk & Management Matrix

Side Effect	Prevalence	Risk Factors	Prevention Strategies
Water Retention	High (common complaint)	• Dose-dependent
• Stimulation of RAAS
• Na+ K+ ATPase activity	• PM/nighttime administration
• Increase potassium intake
• Lower sodium intake
• Slower, gradual dose titration	• Lower the dose to last tolerable point (#1 strategy)
• Split dosing to reduce spikes
• Taurine 2g/day
• ALA 600mg/day
• Consider ACEi or ARB if persistent
Carpal Tunnel Syndrome	Common with water retention	• Edematous synovial tissues compressing nerves	• Gradual titration
• Ergonomic considerations
• B6 as P5P (50-100mg daily)
• Wrist mobility exercises	• Lower the dose to last tolerable point (#1 strategy)
• Sleep mechanics modification
• Wrist braces during sleep
• Reduce repetitive movements
• Taurine 2g/day
• ALA 600mg/day
Elevated Blood Pressure	Medium	• Water retention, Higher doses
• Genetic predisposition
• Na+/K+ imbalance	• Potassium-rich diet
• Regular cardio
• Limit stimulants
• Proper hydration	• Reduce dose if persistent
• Hibiscus tea
• Magnesium (300-400mg)
• Hawthorn extract
• Consider ACEi or ARB if persistent
Insulin Resistance	Increases with dose (>0.01mg/kg/day)	• Higher doses
• Daytime administration
• Excessive calorie surplus	• Nighttime bolus dosing
• Avoid continuous daytime dosing
• Maintain caloric balance	• Prioritize large bolus at night
• Increase steps and cardio
• Sleep quality optimization
• Note: AM fasting glucose may be elevated with PM dosing (acceptable in most cases)
Gynecomastia	Rare	• IGF-1 increasing aromatase expression
• Increased body fat	• Monitor estrogen levels	• Dose adjustment if occurs
• Note: rarest side effect occurrence
Organomegaly & Dermal Changes	Only with extreme dosing	• Extreme doses for extended periods
• Throughout-day dosing	• Moderate dosing
• Periodic lower-dose periods	• Monitor heart (especially with AAS use)
• Occurs primarily in acromegaly, not typical HGH use in healthy individuals
Cancer Risk	N/A - not causative	• Pre-existing cancer
• Family history	• Screening before use	• Not advised for those with existing cancer or strong family history

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General Management Guidelines:

Dosing Strategy:
- Start with lowest effective dose (3-4 IU/day males, 1-2 IU/day females)
- Titrate up cautiously (0.5-1.0 IU weekly) based on response and tolerance
- Adjust between single or split dosing based on response and health markers
Primary Intervention:
- Lowering the dose is consistently the #1 strategy for all side effects
- Split dosing can help reduce acute side effects from large bolus administration
Monitoring:
- Regular assessment of side effects
- Blood glucose monitoring (understanding morning elevation after PM dosing is expected)
- Long-term monitoring of cardiac health, especially with concurrent AAS use
Supplement Support:
- Taurine (2g/day) and ALA (600mg/day) have evidence for managing water retention
- Sleep support if needed
Additional Considerations:
- Limit use of concurrent drugs that compound risks
- Water retention can mask fat loss assessment
- Insulin resistance may be transient at lower doses (<0.01mg/kg/day) </aside>

Reconstitution Calculator

BAC Water Added	10 IU Vial	15 IU Vial	20 IU Vial
1.0 mL	10 IU/ml
0.1 mL = 1 IU	15 IU/mL
0.1 mL = 1.5 IU	20 IU/mL
0.1 mL = 2 IU
2.0 mL	5 IU/mL
0.1 mL = 0.5 IU	7.5 IU/mL
0.1 ml = 0.75 IU	10 IU/mL
0.1mL = 1 IU
3.0 mL	3.3 IU/mL
0.1 mL = 0.33 IU	5 IU/mL
0.1 mL = 0.5 IU	6.7 IU/mL
0.1 mL = 0.67 IU

Note: On a standard U-100 insulin syringe, 0.1ml corresponds to the '10 unit' marking on the syringe. Always verify which scale your syringe uses, as some countries use different standards.

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Additional Clarifications

Visual Reference for Syringe Markings
- On standard U-100 insulin syringes common in the US: 0.1ml = 10 units, 0.05ml = 5 units, 0.01ml = 1 unit
- Different countries may use different syringe scales - always confirm your specific syringe measurements
Common Reconstitution Examples
- Example 1: 10IU vial with 1ml bacteriostatic water = 10IU per ml (10 units on syringe = 1IU HGH)
- Example 2: 10IU vial with 2ml bacteriostatic water = 5IU per ml (10 units on syringe = 0.5IU HGH)
- Example 3: 10IU vial with 0.5ml bacteriostatic water = 20IU per ml (10 units on syringe = 2IU HGH)
Precision Considerations
- For doses under 2IU, consider using more dilute reconstitution (2ml+ of water) for greater accuracy
- For micro-dosing (under 1IU), consider low-volume insulin syringes (0.3ml/0.5ml) for better precision
Stability Notes
- More concentrated solutions may maintain stability slightly longer
- More dilute solutions can make smaller doses easier to measure accurately
- Regardless of concentration, reconstituted HGH should be used within 3-4 weeks when refrigerated
Reconstitution Best Practices
- Ensure both vial and bacteriostatic water are at room temperature before reconstitution
- Inject bac water slowly down the side of the vial, not directly onto the powder
- Gently swirl (never shake) until completely dissolved; foaming can denature the peptide
- Inspect solution for clarity; should be completely clear with no visible particles
- Allow bubbles to settle before drawing your dose
Measurement Conversions
- 1 ml = 1 cc = 100 units on U-100 insulin syringe
- Syringe Size ≠ Needle Size: A 0.5ml syringe can have various needle gauges (e.g., 29G, 30G, 31G)
Peptide Calculator
- For precise calculations based on your specific vial size and desired concentration, use our peptide calculator at: https://particlepeptides.com/en/content/48-peptide-calculator
- The calculator helps eliminate guesswork and potential dosing errors </aside>

Diagrams and Decision Trees

Direct Link to Mind Map: https://miro.com/app/board/uXjVI4bNdxY=/?share_link_id=411003482969

https://miro.com/app/board/uXjVI4bNdxY=/?share_link_id=400892485874